Differences between small resistance arteries (mesenteric and pancreatic) on vascular remodeling in protein restriction diet

Abstract

Protein malnutrition during early stages of development can result in cardiometabolic disorders in adulthood such as insulin resistance, diabetes, and hypertension. Vascular remodeling is a common feature of several cardiovascular diseases. The resistance arteries control the blood flow in different tissues, and are a blood pressure modulator. Vascular remodeling on small arteries induced by restricted- protein- diet might in different modulation of regional vascular resistance and blood flow. However, whether or not a protein restriction diet in the early stages of development is associated with a remodeling of resistance arteries is still not known. In this context, the present study evaluate the morphology and structural parameters of resistance arteries from the mesenteric and pancreatic vascular beds of mice fed a post-weaning protein-restricted diet.