Evaluation of the effect of culture supernatant of keratinocytes in hyperalgesia model

Abstract

Inflammation is a defense response against human death by physical, chemical or biological agents, which triggers, among other factors, pain. Despite being a warning and protection signal, it decreases the life quality.In view of this, research into new antinociceptive therapeutic options is necessary. As it was verified that the keratinocytes of the basal stratum of the epidermis release endogenous opioid, being an important antinociceptive mechanism, the best understanding of the relationship between peripheral nervous system, skin (keratinocytes) and analgesia is important.Thus, the present study aims to evaluate the analgesic potential of culture supernatant of human keratinocytes in the experimental model of inflammatory hyperalgesia. The purpose of it is to establish the anti-hyperalgesic mechanism and time of action, which may bring a new way of local treatment of inflammatory hyperalgesia.