Keywords
Nephotric syndrome
NPHS2 gene
Promoter variants.
NPHS2 gene
Promoter variants.
How to Cite
SILVA, Joao Victor Virgilio da; GUARAGNA, Mara Sanches; LUTAIF, Anna Cristina Gervásio de Brito; GUERRA, Andréa Trevas Maciel; BELANGERO, Vera Maria Santoro; GUERRA JÚNIOR, Gil; MELLO, Maricilda Palandi de. Funcional analysis of variants in NPHS2 promoter identified in brazilian patients with nephrotic syndrome. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 26, 2019. DOI: 10.20396/revpibic262018682. Disponível em: https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/682. Acesso em: 28 aug. 2026.
Abstract
Nephrotic syndrome is defined by heavy proteinuria, hypoalbuminemia, edema and hyperlipidemia. Podocin (NPHS2) is an integral membrane protein of podocytes in the glomerular filtration barrier. The aim of this study was to verify if different variants, previously identified in the promoter region of NPHS2 gene in non-related SRNS patients, affect podocin expression.
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Copyright (c) 2019 Joao Victor Virgilio da Silva, Mara Sanches Guaragna