Studies towards the production of candicidin by Streptomyces sp. CBMAI 2043

Resumo

The aim of this study was to explore two gene clusters from Streptomyces sp. CBMAI 2043. One of them was the candicidin gene cluster, a polyketide annotated form the strain whole genome sequencing. By deleting important genes it is possible to have clues about the biosynthetic pathways and released intermediates. The second gene is a unknown non ribosomal. Using the same approach we expected to ,correlate the gene cluster to the chemical entity. These studies will help to have a better understanding of the whole matabolite profile of the wild type strain.