Palavras-chave
Chlorambucil
Heck reaction
Redox relay
Heck reaction
Redox relay
Como Citar
SANTANA, Victor; BUFFON, Regina. The Heck reaction applied to the synthesis of chlorambucil. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 27, p. 1–1, 2019. DOI: 10.20396/revpibic2720192201. Disponível em: https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2201. Acesso em: 18 mar. 2026.
Resumo
The Heck reaction plays an important role in organic synthesis because of the versatility of aryl halides and olefins that can be employed. Therefore, a synthetic route to chlorambucil through the Heck reaction was proposed. However, the oxidative addition of the proposed halide to the palladium catalyst was not sucessful. An alternative Heck-Matsuda approach showed better results for the synthesis of a carboxylic acid derivative of chlorambucil.
Referências
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Werner, E. W.; Mei, T. –S.; Burckle, A. J. & Sigman, M. S. Science 2012 1455-1458.
Polo, E. C. & Dias, L. C. J. Org. Chem. 2017 4072-4112.
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