Palavras-chave
Acyl-hydrazones
Acetylcholinesterase
Pharmacokinetic properties
Acetylcholinesterase
Pharmacokinetic properties
Como Citar
FRIAS, Camila; ALMEIDA, Wanda. Synthesis of novel acyl-hydrazones as potential dual binding ligands for acetylcholinesterase: Biological evaluation and in silico pharmacokinetic profile prediction. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 27, p. 1–1, 2019. DOI: 10.20396/revpibic2720192568. Disponível em: https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2568. Acesso em: 18 mar. 2026.
Resumo
The current project has as its goal synthesizing a series of novel acyl-hydrazones, to be evaluated against Alzheimer's Disease neuropathological markers; and also studying the synthesized compounds' effects over acetylcholinesterase and its antioxidant activities.
Referências
Alzheimer’s Association. Alzheimer’s disease facts and figures. 2019, 15,87;
da Silva, G. S.. Figueiró, M.; Tormena, C. F., et al. J. Enz.Inhib. Med. Chem., 2016, 31, 1464;
Ellman, G. L., Courtney, K. D., Andres, V. & Featherstone, R. M.. Biochem. Pharmacol. 1961, 7, 27;
Brand-Williams, W., Cuvelier, M. E. Food Sci. Technol. 1995, 28, 25;
Daina, A.; Michelin, O.; Zoete, V. Sci. Rep., 2016, 7, 42717.
da Silva, G. S.. Figueiró, M.; Tormena, C. F., et al. J. Enz.Inhib. Med. Chem., 2016, 31, 1464;
Ellman, G. L., Courtney, K. D., Andres, V. & Featherstone, R. M.. Biochem. Pharmacol. 1961, 7, 27;
Brand-Williams, W., Cuvelier, M. E. Food Sci. Technol. 1995, 28, 25;
Daina, A.; Michelin, O.; Zoete, V. Sci. Rep., 2016, 7, 42717.
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