Palavras-chave
Histones
Epigenetic process
Lip neoplasm
Epigenetic process
Lip neoplasm
Como Citar
ESTEVAN, Mariana; VARGAS, Pablo; AMARAL-SILVA, Gleyson; WAGNER, Vivian; MARIZ, Bruno; SANTOS-SILVA, Alan; LOPES, Marcio; ALMEIDA, Oslei. Evaluation of the H3K9ac immunoexpression in lip carcinogenesis. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 27, p. 1–1, 2019. DOI: 10.20396/revpibic2720192623. Disponível em: https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/2623. Acesso em: 18 mar. 2026.
Resumo
Actinic cheilitis (AC) is a potentially malignant lesion caused by long period sun exposure. Mainly affects the lower lip and can develop into a lip squamous cell carcinoma (LSCC). Acetylation of lysine 9 in histone 3 (H3K9ac) is an epigenetic mechanism that regulates gene expression by chromatin decondensation. H3K9ac was more intense in LSCC (n=40) than AC (n=42) and LNM(n=47). No differences were observed between LSCC and AC (WHO – Severe dysplasia; Binary System – High risk). Our results suggest that H3K9ac could be a promising marker to indicate AC’s malignization.
Referências
Webber LP, Wagner VP, Curra M, Vargas PA, Meurer L, Carrard VC, et al. Hypoacetylation of acetyl-histone H3 (H3K9ac) as marker of poor prognosis in oral cancer. Histopathology. 2017 Mar 22;38(1):42–9.
El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2017. 347 p.
El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2017. 347 p.
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