Congenital megacolon: morfofunctional remainings on rat colon after benzalkonium chloride treatment

Resumo

Hirschsprung's disease is characterized by colonic aganglionosis, affecting mainly newborns. The current treatment of this pathology is surgical, but several studies are underway to develop less invasive methods that could cause less comorbidities. These studies use congenital megacolon models, one of which uses benzalkonium chloride to cause neurogenic ablation. The objective of this study is to demonstrate the effectiveness of aganglionosis provided by this drug by describing the remaining cells after denervation in order to optimize studies that use this model later.