Keywords
Experimental autoimmune encephalomyelitis
T CD4 cells
JAK/STAT/SOCS.
T CD4 cells
JAK/STAT/SOCS.
How to Cite
CAMPOS, Bruna Bueno de; FARIAS, Alessandro dos Santos; COCENZA, Rani; PRADELLA, Fernando. Study of the switch-over from the profile Th17 lymphocytes to Th1-like during the evolution of experimental autoimmune encephalomyelitis. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 26, 2018. DOI: 10.20396/revpibic262018222. Disponível em: https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/222. Acesso em: 21 apr. 2026.
Abstract
It has been demonstrated the cytotoxic activity of TCD4+ encaphalitogenic lymphocytes and it's crucial role in the development of Experimental Autoimmune Encephalomyelitis (EAE). Furthermore, our laboratory has seen a switch from Th17 profile to Th1-like during the evolution of EAE. Thus, these lymphocytes decreased IL-17A production while begin to produce IFN? when infiltrate the central nervous system. Therefore, our goal was to verify the mechanisms that governs the convertion of Th17 cells into IFN?-producing cells.
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Copyright (c) 2018 Bruna Bueno de Campos, Alessandro dos Santos Farias