No. 26 (2018), Resumos
No. 26 (2018)

Excipient suitability for freeze-dried protein solutions

Resumos
Published 2019-01-07
Giovanna Sevilha Ferreira
Universidade Estadual de Campinas
Laura de Oliveira Nascimento
Universidade Estadual de Campinas
Danilo Costa Geraldes
Universidade Estadual de Campinas
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Keywords

Lyophilization
Pre-formulation
Excipients.

How to Cite

FERREIRA, Giovanna Sevilha; NASCIMENTO, Laura de Oliveira; GERALDES, Danilo Costa. Excipient suitability for freeze-dried protein solutions. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 26, 2019. DOI: 10.20396/revpibic262018541. Disponível em: https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/541. Acesso em: 29 sep. 2026.
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Abstract

This work focused on pre-formulation studies for freeze-dried protein formulations, using albumin as a model protein. Two aminoacids and two sugars were selected as lyoprotectors and studied according a mixture design (simplex-lattice). Sample characterization included total protein content, collapse temperature and visual inspection. Sugar formulations collapsed, but not aminoacids, which indicate non sugar excipients as the best choice under the studied conditions.

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Copyright (c) 2019 Giovanna Sevilha Ferreira, Laura de Oliveira Nascimento