The impact of different seizure control in brain atrophy in temporal lobe epilepsy: a voxel based morphometry analysis

Abstract

Temporal Lobe Epilepsy (TLE) is the most common epileptic syndrome in adult, with a high documented drug resistance rate. There are many forms of presentation of TLE, that varies significantly in severity and seizure control. Many studies have shown brain atrophy in patients with temporal lobe epilepsy, but few have compared the impact of refractory seizures on grey and white matter atrophy. In this study we applied voxel-based morphometry (VBM), a MRI morphometric technique largely used in epilepsy and others neurological disorders, to evaluate the relation between severity of the disease and brain atrophy in TLE patients.