Investigation of changes in the expression of human blood plasma proteins in major depressive disorder patients associated to an effective antidepressant response

Resumo

Major depressive disorder is a complex multi-factor psychiatric disorder whose consequences can be debilitating, being one of the main worldwide causes of suicide. Its treatment is predominantly antidepressants and regular counseling and despite the treatment’s effectiveness, 10-30% of the patients respond differently and present adverse reactions to it, which can lead to the a change in the medication used. Due to this, it is important to understand what differs in patient’s blood plasma protein that can help identify good and bad responders to treatment. Through the analysis of differential expressed protein in good responders, it is possible to investigate which biochemical processes vary between them and therefore predict possible responses to better adapt patient’s treatment.