No. 26 (2018), Resumos
No. 26 (2018)

Towards the total synthesis of the labdane diterpenes Cacofurans A and B

Resumos
Published 2019-02-15
Pedro Manoel Barreto de Abreu
Universidade Estadual de Campinas
Julio Cezar Pastre
Universidade Estadual de Campinas
Luiz Fernando Toneto Novaes
Universidade Estadual de Campinas
Mateus Lançanova Stivanin
Universidade Estadual de Campinas
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Keywords

Total synthesis
Diterpens
Cacofurans.

How to Cite

ABREU, Pedro Manoel Barreto de; PASTRE, Julio Cezar; NOVAES, Luiz Fernando Toneto; STIVANIN, Mateus Lançanova. Towards the total synthesis of the labdane diterpenes Cacofurans A and B. Revista dos Trabalhos de Iniciação Científica da UNICAMP, Campinas, SP, n. 26, 2019. DOI: 10.20396/revpibic2620181144. Disponível em: https://econtents.sbu.unicamp.br/eventos/index.php/pibic/article/view/1144. Acesso em: 22 apr. 2026.
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Abstract

Cacospongia sp. is a species of marine sponge that produces labdane-class diterpens known as Cacofurans A and B, which show cytotoxic activity in vitro. In this work, we present the synthetic pathway of Cacofurans A and B in ten and nine steps, respectively. Five steps of the synthetic proposal were completed, with 25% overall yield, including the formation of a five-membered ring using the Suárez reaction. After the completion of the total synthesis, the cytotoxic potential of Cacofurans A and B will be evaluated.

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Copyright (c) 2019 Pedro Manoel Barreto de Abreu, Julio Cezar Pastre